c1418 Born in Borgo Sansepolcro, near Arezzo in eastern Tuscany.
1439–40 Piero works with Domenico Veneziano in Florence on frescoes for the church of Sant’Egidio which are now lost. While in Florence he witnesses a visit by the Byzantine emperor John VIII Paleologus.
1442 He is back in Borgo Sansepolcro, where he is a candidate for a position on the Town Council.
1445 A contract is signed commissioning Piero to produce a polyptych of the Madonna della Misericordia for the Compagnia della Misericordia in Borgo.
1449–51 Works for Sigismondo Malatesta in Rimini and the Este family in Ferrara.
1452 Piero begins the fresco cycle of the Legend of the True Cross in the church of San Francesco in Arezzo.
1458-9 Piero is in Rome working on frescoes (now lost) in the Vatican but is also engaged in The Resurrection and the unfinished Madonna della Misericordia, both in Borgo.
1460–70 Works in Borgo, Arezzo and Perugia.
1469 Stays in Urbino with Giovanni Santi, the father of Raphael.
1474–8 He is again in Urbino working for Federico da Montefeltro.
After 1478 Spends most of his time in Borgo Sansepolcro; it is at this time that he produces his treatises on perspective.
1492 Dies and is buried at Borgo Sansepolcro.
1445 Madonna della Misericordia, Sansepolcro, Pinacoteca Communale
1451 Portrait of Sigismondo Pandolfo Malatesta, Paris, Musée du Louvre
c1455 The Baptism of Christ, London, National Gallery
c1456 Legend of the True Cross (fresco cycle), Arezzo, San Francesco
1457 The Flagellation,Urbino, Galleria Nazionale delle Marche
c1460 Madonna del Parto, Monterchi, Museo della Madonna del Parto
c1465 Battista Sforza, Duchess of Urbino, Florence, Galleria degli Uffizi
c1465 Federigo de Montefeltro, Duke of Urbino, Florence, Galleria degli Uffizi
1465 Resurrection of Christ, Sansepolcro, Pinacoteca Communale
1454-69 St John the Evangelist (fragment), New York, Frick Collection
1469 St Michael,London, National Gallery
1472-4 Montefeltro Altarpiece, Milan, Pinacoteca Brera
1470-75 The Nativity, London, National Gallery